The University of the Philippines Manila (UPM) is a state-funded medical and research university located in Ermita, Manila, Philippines. It is known for being country's center of excellence in the health sciences, including health professional education, training, and research. It is the oldest of the seven constituent universities of the University of the Philippines System, even predating the founding of UP by three years. Originally established on December 1, 1905 as the Philippine Medical School and later called as the UP College of Medicine and Surgery on June 10, 1907. It was renamed as University of the Philippines Manila in 1983. UP Manila administers and operates the Philippine General Hospital, the largest medical center and the national referral center for health in the Philippines. The university is also the home of the National Institutes of Health.